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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in adults with a body mass index (BMI) in excess of 27, provided they also experience weight-related medical issues such as Tupe2 diabestes, high-cholesterol and/or hypertension (blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder in addition to being an aid to stop smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle which includes a reduced-calorie exercise and dieting, Contrave provides another treatment option for chronic weight management for people who are obese or are overweight and have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular physical exercise. Results from a medical trial that enrolled patients without diabetes indicated that patients had a normal weight loss of 4.1% instead of participants have been given placebos) during a 12- month period, while a different study involving patients with diabetes had a typical weight loss of 2% over treatment with placebo at one year. Using two separate drugs to lose weight naturally can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it you ought to err to the side of caution and permit the FDA do its job and demand some research be done so your public knows the side effects and dangers of the medications before we take them. Keep in mind that drug companies have been in business to earn money and that they would say anything to keep people on their medications. Researchers found that participants investing in this drug for a year, lost weight within one month and have kept the extra weight off during the entire 56 weeks from the study. Contrave is really a combination with the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs that are made up of multiple active ingredient, which can make them more potent and safer. Combo-pilling is the newest fad or also the newest ahead under scrutiny and so it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills is now popular is the fact that since right now there aren't long term prescription diet pills that have been licensed by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be licensed by the FDA. Seizures are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug also can raise blood pressure levels and heart rate, and really should not be used in people with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure and heart rate and must stop used in patients with uncontrolled high blood pressure, as well as by a person with heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients which has a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients for the increased likelihood of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking. 'The intent of the bill would be to give police officers and district attorneys an instrument to address illicit drug use among expecting mothers through treatment programs," Tennessee governor Bill Haslam said.